Activation of GPER1 in macrophages ameliorates UUO-induced renal fibrosis
Abstract Numerous studies have proven the critical role of macrophages in the renal fibrosis process.Notably, G Protein-coupled Estrogen Receptor 1 (GPER1), a novel estrogen receptor, has been shown to play a ubiquitous role in regulating macrophage activities and proinflammatory pathways.However, the precise role of GPER1 in macrophage-mediated re